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ChemInform Abstract: First Asymmetric Organocatalyzed Domino Friedel-Crafts/Lactonization Reaction in the Enantioselective Synthesis of the GABAB Receptor Modulator (S)-BHFF
- Source :
- ChemInform. 47
- Publication Year :
- 2016
- Publisher :
- Wiley, 2016.
-
Abstract
- An asymmetric domino Friedel–Crafts/lactonization sequence between phenols and trifluoropyruvate has been accomplished for the first enantioselective synthesis of ( S )-BHFF, a positive allosteric modulator (PAM) of GABA B receptor. The developed protocol leads to 3-OH-benzofuranone derivatives bearing a quaternary stereogenic center, and gives a valuable access to bioactive compounds with promising pharmaceutical applications.
Details
- ISSN :
- 09317597
- Volume :
- 47
- Database :
- OpenAIRE
- Journal :
- ChemInform
- Accession number :
- edsair.doi...........60dad7ae6702992874d785a63c100d85
- Full Text :
- https://doi.org/10.1002/chin.201622116