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Effect of fresh human amniotic membrane on radiation-induced wounds in a murine experimental model
- Source :
- European Journal of Plastic Surgery. 41:279-284
- Publication Year :
- 2017
- Publisher :
- Springer Science and Business Media LLC, 2017.
-
Abstract
- Radiation-induced wounds are extremely difficult to treat. They may lead to severe infections and can even be life-threatening. Wound dressings, negative pressure wound treatment, hyperbaric oxygen therapy, and antibiotics are the main treatment modalities for radiation-induced wounds. Amniotic membrane is the innermost surface of the placenta. It has been shown that amniotic membrane induces re-epithelization, regulates angiogenesis, and decreases inflammation and fibrosis. Our proposed theory was that amniotic membrane can have a role in treating radiation-induced wounds by inducing epithelization and increasing wound tensile strength. Out of 24 rats, 3 groups were composed. In group A, 21 days after one session of radiotherapy, a 2-cm incision was made on the gluteal region then an amniotic membrane was placed under the skin flaps. In group B, 21 days after one session of radiotherapy, a 2-cm incision made on the gluteal region and wound is sutured back after 2 × 2 cm of area was undermined. In group C, no radiotherapy is given. We just made an incision and sutured it back again with the same size of area undermined. Three weeks after these surgeries, wound regions were excised en bloc and taken out for biomechanical and histopathological assessments. The end results in amniotic membrane group (group A) were statistically higher than those in the other groups in the terms of wound healing and biomechanical measurements. After biomechanical and histopathological evaluation, amniotic membrane, with its antimicrobial, anti-inflammatory, angiogenic, and epithelial-inductive effects, was found to be affective in post-radiation wound treatment. Due to the features of amniotic membrane mentioned above, it can be an option in treatment of patients which received neoadjuvant radiotherapy to prevent future wounds. It can also be used for the care and treatment of post-radiation wounds. Level of Evidence: Not ratable
- Subjects :
- medicine.medical_specialty
integumentary system
business.industry
Angiogenesis
medicine.drug_class
medicine.medical_treatment
Antibiotics
Inflammation
Radiation induced
030206 dentistry
medicine.disease
Surgery
Radiation therapy
03 medical and health sciences
Plastic surgery
0302 clinical medicine
Fibrosis
030220 oncology & carcinogenesis
Medicine
medicine.symptom
business
Wound healing
Subjects
Details
- ISSN :
- 14350130 and 0930343X
- Volume :
- 41
- Database :
- OpenAIRE
- Journal :
- European Journal of Plastic Surgery
- Accession number :
- edsair.doi...........62686380ab87081d9657479dfd721e7f