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Phenotypic variation in mitochondrial function across New Zealand snail populations
- Publication Year :
- 2017
- Publisher :
- Cold Spring Harbor Laboratory, 2017.
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Abstract
- Mitochondrial function is critical for energy homeostasis and should shape how genetic variation in metabolism is transmitted through levels of biological organization to generate stability in organismal performance. Mitochondrial function is encoded by genes in two distinct and separately inherited genomes – the mitochondrial genome and the nuclear genome – and selection is expected to maintain functional mito-nuclear interactions. Nevertheless, high levels of polymorphism in genes involved in these mito-nuclear interactions and variation for mitochondrial function are nevertheless frequently observed, demanding an explanation for how and why variability in such a fundamental trait is maintained.Potamopyrgus antipodarumis a New Zealand freshwater snail with coexisting sexual and asexual individuals and, accordingly, contrasting systems of separate vs. co-inheritance of nuclear and mitochondrial genomes. As such, this snail provides a powerful means to dissect the evolutionary and functional consequences of mito-nuclear variation. The lakes inhabited byP. antipodarumspan wide environmental gradients, with substantial across-lake genetic structure and mito-nuclear discordance. This situation allows us to use comparisons across reproductive modes and lakes to partition variation in cellular respiration across genetic and environmental axes. Here, we integrated cellular, physiological, and behavioral approaches to quantify variation in mitochondrial function across a diverse set of wildP. antipodarumlineages. We found extensive across-lake variation in organismal oxygen consumption, mitochondrial membrane potential, and behavioral response to heat stress, but few global effects of reproductive mode or sex. Taken together, our data set the stage for applying this important model system for sexual reproduction and polyploidy to dissecting the complex relationships between mito-nuclear variation, performance, plasticity, and fitness in natural populations.
- Subjects :
- 0106 biological sciences
0303 health sciences
Mitochondrial DNA
Nuclear gene
biology
biology.organism_classification
010603 evolutionary biology
01 natural sciences
Genome
6. Clean water
Sexual reproduction
03 medical and health sciences
Evolutionary biology
Genetic variation
Genetic structure
Gene
Potamopyrgus antipodarum
030304 developmental biology
Subjects
Details
- Database :
- OpenAIRE
- Accession number :
- edsair.doi...........62755db21978b9f4b78bf4db5195a629