ChemInform Abstract: A Facile and Efficient Synthesis of Polycyclic Spiropyrrolidine Oxindoles Bearing Mesityl Oxide Unit via a Three-Component 1,3-Dipolar Cycloaddition Reaction

A facile and efficient methodology is developed for the synthesis of multifunctional polycyclic spiropyrrolidine oxindoles via a three-component 1,3-dipolar cycloaddition reaction of dienones (III) with azomethine ylides (thermally generated in situ from isatin derivatives and proline or thioproline).