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Histological Study and DNA Changes in the Kidneys of Rat Fetuses Maternally Treated with Clarithromycin
- Source :
- The Egyptian Journal of Hospital Medicine. 61:575-590
- Publication Year :
- 2015
- Publisher :
- Egypts Presidential Specialized Council for Education and Scientific Research, 2015.
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Abstract
- Introduction: macrolide antibiotics are a class of potent and well established antimicrobials that also possess anti-inflammatory and/or immunomodulatory properties. Because of their size, lower levels of macrolides are able to reach the developing fetuses. Materials and method: the pregnant rats were orally administered with clarithromycin at early and late gestational periods. The 20 day-old fetuses were dissected for excision of the kidney. Half of the kidney was processed and stained with H & E, PAS, Masson’s trichrome and Feulgen techniques then followed by morphometric measurements and statistical study. The other half of the kidney was preserved for DNA fragmentation assay.Results: This study revealed that clarithromycin administration to pregnant rats showed different histopathological, histochemical and DNA changes in the kidneys of their fetuses. Conclusion: Administration of the antimicrobial agent; clarithromycin at early and late gestational periods exhibits nephrotoxicity in the developing fetuses.
Details
- ISSN :
- 16872002
- Volume :
- 61
- Database :
- OpenAIRE
- Journal :
- The Egyptian Journal of Hospital Medicine
- Accession number :
- edsair.doi...........6391c808c457b610b00872e0b36ad54a