New Triterpenoid Saponins from the Roots ofGypsophila paniculataL

The seven new triterpenoid saponins 1–7 were isolated from the roots of Gypsophila paniculata L. Their structures were established by 1D- and 2D-NMR techniques, HR-MS, and acid hydrolysis. The isolated compounds include 3,28-O-bidesmosides with or without a 4-methoxycinnamoyl group (see 1vs.2 and 3), and 3-O-monoglucosides 4–7. All isolated saponins 1–7 and their aglycones were evaluated for their α-glucosidase inhibition activity. Compound 1 showed inhibitory activity against yeast α-glucosidase with an IC50 value of 100.9±3.3 μM, whereas compounds 2–7 were inactive.