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Pharmacokinetic of simvastatin at experimental hypothyreosis

Authors :
E N Yakusheva
N M Popova
Source :
I.P. Pavlov Russian Medical Biological Herald. 19:38-42
Publication Year :
2011
Publisher :
ECO-Vector LLC, 2011.

Abstract

In article data of the research devoted to studying of pharmacokinetic of simvastatin at experimental hypothyreosis are resulted. It is shown changes of pharmacokinetic parameters of main metabolite of drug – β-hydroxyacid of simvastatin, which says about decrease of bioavailability and correlation of these changes with level of T4.

Subjects

Subjects :
Drug
business.industry
media_common.quotation_subject
Metabolite
nutritional and metabolic diseases
Pharmacology
Bioavailability
chemistry.chemical_compound
chemistry
Pharmacokinetics
Simvastatin
polycyclic compounds
medicine
lipids (amino acids, peptides, and proteins)
sense organs
skin and connective tissue diseases
business
media_common
medicine.drug

Details

ISSN :
25002546 and 02043475
Volume :
19
Database :
OpenAIRE
Journal :
I.P. Pavlov Russian Medical Biological Herald
Accession number :
edsair.doi...........653e8c1882c8f5717b0d2011c4c2e3e0

Tools

Authors Abstract Subjects Details