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Anion selective chromogenic and fluorogenic chemosensor and its application in breast cancer live cell imaging
- Source :
- RSC Adv.. 4:41446-41452
- Publication Year :
- 2014
- Publisher :
- Royal Society of Chemistry (RSC), 2014.
-
Abstract
- A novel Schiff base receptor (L) bearing catechol and phenol groups was synthesized and characterized by various spectral (FTIR, 1H NMR and mass) data. The anion recognition ability of L was investigated by experimental (UV-Vis, fluorescence and 1H NMR) and theoretical (B3LYP/6-31G**) methods. Among the tested anions, the receptor L showed both naked-eye detectable color change from light-yellow to intense brownish-yellow and spectral (hyperchromic shift at 450 nm and ‘turn-on’ fluorescence at 480 nm) changes selectively towards F− and AcO− in DMSO and mixed DMSO–H2O medium because of the formation of a hydrogen bonded anion-receptor complex followed by the deprotonation of L. The receptor L was tested for live breast cancer cell imaging and can be applied to the breast tumour diagnosis.
Details
- ISSN :
- 20462069
- Volume :
- 4
- Database :
- OpenAIRE
- Journal :
- RSC Adv.
- Accession number :
- edsair.doi...........65c8db9841d18455c8bf60108859db41