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Metal-Free C(sp3)–H Amination of 2-Oxindoles in Water: Facile Synthesis of 3-Substituted 3-Aminooxindoles
- Source :
- ACS Sustainable Chemistry & Engineering. 6:5615-5619
- Publication Year :
- 2018
- Publisher :
- American Chemical Society (ACS), 2018.
-
Abstract
- A novel metal-free C(sp3)–H amination of 2-oxindoles with alkylamines to afford C–N coupling products under mild conditions has been exploited. A series of 3-substituted 2-oxindoles and primary/secondary amines substrates were found to be well tolerated, affording the corresponding 3-substituted 3-aminooxindoles in 43%–92% yields. This method uses the economical and environmentally friendly “I2–TBHP” system, and the mechanistic studies revealed that the procedure undergoes through a radical pathway.
- Subjects :
- Primary (chemistry)
010405 organic chemistry
Renewable Energy, Sustainability and the Environment
Chemistry
General Chemical Engineering
Radical
General Chemistry
010402 general chemistry
01 natural sciences
Environmentally friendly
Combinatorial chemistry
0104 chemical sciences
Coupling (electronics)
Metal free
Environmental Chemistry
Amination
Subjects
Details
- ISSN :
- 21680485
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- ACS Sustainable Chemistry & Engineering
- Accession number :
- edsair.doi...........66310752b2ffb6a8ecf8f74f36b223b4