The Effects of 6 Weeks of Resistance Training on the Gut Microbiome and Cardiometabolic Health in Young Adults with Overweight and Obesity

INTRODUCTIONObesity is a known risk factor for the development of insulin resistance and other cardiometabolic disorders. Recently, the gut microbiome has been associated with obesity and subsequent health complications. Exercise has been regularly utilized as a therapeutic intervention to treat obesity and its associated comorbidities. This study examined the effects of a 6-week resistance training exercise program (RT) on the diversity, composition, and metabolic pathways of the gut microbiome.METHODSSedentary young adults (age 18-35 years) with overweight and obesity (BMI 25-45 kg/m2) were recruited to participate in this randomized controlled trial. Participants were randomized to RT (n=16), a 6-week resistance training program (3 days/week), or control (CT) (n=16), a non-exercising control. Main outcomes of the study included gut microbiome measures (taxa abundances, diversity, and predicted function) and cardiometabolic outcomes (blood pressure (BP) and glucoregulation).RESULTSIncreased abundances ofRoseburia, a short chain fatty acid (SCFA) producer and predicted starch and sucrose metabolism pathway were observed over 6 weeks (W6) with RT in comparison to CT (group × week, pCONCLUSIONThis study provides preliminary evidence that resistance training increases abundance of selected SCFA producers and microbial pathways and improves cardiometabolic health. Additionally, the associations of cardiometabolic indicators with the microbial community structure warrants further investigation.