Surgical adhesive: Synthesis and properties of thermoresponsive Pluronic L-31-3,4-dihydroxyphenylalanine-arginine derivatives

A novel thermosensitive adhesive was synthesized by the esterification reaction of multihydroxyl Pluronic L-31 with 3,4-dihydroxy-l-phenylalanine and l-arginine. Pluronic L-31–DOPA–arginine derivative (PDA) gels, rapidly formed in situ with horseradish peroxidase and hydrogen peroxide, were used to explore the performance of efficient tissue adhesives. The results of their adhesive strength on porcine skin demonstrate that the structure of the polymers and temperature influenced the adhesiveness to tissue of the polymers. Compared with the PDAs at 25 °C, the PDAs at 37 °C showed superior adhesive strength. The attractive performance of the PDA gels were demonstrated by this study's results, which suggest biomedical applications in tissue-adhesive devices in the future. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 44729.