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Urothelium-derived inhibitory factor(s) influences on detrusor muscle contractilityin vitro
- Source :
- British Journal of Pharmacology. 129:416-419
- Publication Year :
- 2000
- Publisher :
- Wiley, 2000.
-
Abstract
- The function of the bladder urothelium in modulating contractile responses of the underlying detrusor smooth muscle to muscarinic stimulation has been examined in the pig bladder. Saturation curves for [3H]-QNB binding demonstrated a greater muscarinic receptor density in the urothelium than in the detrusor smooth muscle. The presence of an intact urothelium on isolated bladder strips inhibited contractions induced by carbachol but not KCl. Contractions of a urothelium-denuded muscle strip were inhibited in the presence of a second bladder strip with an intact urothelium, but not if the second strip was denuded. The urothelium-induced inhibition of contractions was not prevented in the presence of L-NOARG, methylene blue, indomethacin, propranolol, suramin, TEA or apamin. The data suggest the presence of a diffusable, urothelium-derived inhibitory factor, which could not be identified but appears to be neither nitric oxide, a cyclo-oxygenase product, a catecholamine, adenosine, GABA nor an EDHF sensitive to apamin.
- Subjects :
- Pharmacology
Detrusor muscle
medicine.medical_specialty
Urinary bladder
Carbachol
urogenital system
Chemistry
Pig bladder
urologic and male genital diseases
Apamin
female genital diseases and pregnancy complications
Bladder Urothelium
chemistry.chemical_compound
Endocrinology
medicine.anatomical_structure
Internal medicine
medicine
Urothelium
medicine.symptom
tissues
medicine.drug
Muscle contraction
Subjects
Details
- ISSN :
- 00071188
- Volume :
- 129
- Database :
- OpenAIRE
- Journal :
- British Journal of Pharmacology
- Accession number :
- edsair.doi...........66d445e00e43075cccb1ea12b3f1e450