Risk models predicting survival after reduced-intensity transplantation for myelofibrosis

Summary To define a prognostic model for predicting outcome of reduced-intensity allogeneic stem cell transplantation (RIC-ASCT) for myelofibrosis we evaluated 150 homogenously treated patients and developed a new risk score for overall survival (OS). In a multivariate Cox model for OS, only JAK2 V617F wild-type, age ‡57 years and constitutional symptoms were independently predictive for OS (Hazard Ratio: 2AE02; 2AE43 and 2AE80 respectively). Depending on the presence of one, two or all of these factors, HR of death was 3AE08; 4AE70 and 16AE61 respectively (P