Back to Search Start Over

A case of metastatic testicular germ-cell tumor with rhabdomyosarcoma successfully treated with germ-cell tumor-oriented chemotherapy

A case of metastatic testicular germ-cell tumor with rhabdomyosarcoma successfully treated with germ-cell tumor-oriented chemotherapy

Authors :
Junichiro Ishioka
Fumitaka Koga
Minato Yokoyama
Kazutaka Saito
Kazunori Kihara
Toshiki Kijima
Yasuhisa Fujii
Hitoshi Masuda
Makoto Kagawa
Noboru Numao
Yoh Matsuoka
Source :
International Cancer Conference Journal. 1:58-62
Publication Year :
2011
Publisher :
Springer Science and Business Media LLC, 2011.

Abstract

We report a case of metastatic testicular germ-cell tumor (GCT) with malignant transformation (MT) successfully treated with a GCT-oriented chemotherapy followed by surgery. A 48-year-old man presented with a right testicular tumor with retroperitoneal lymph node metastases. Pathological examination revealed that the primary tumor was rhabdomyosarcoma with mature teratoma, and the rhabdomyosarcoma element expressed placental alkaline phosphatase (PLAP) which is a marker of primitive germ cells or GCTs. After 4 cycles of GCT-oriented chemotherapy (VIP: etoposide, ifosfamide, and cisplatin), radiological partial response of retroperitoneal metastases was achieved, and subsequent retroperitoneal lymph node dissection revealed no remaining tumor cells. Our report suggests that GCT-oriented chemotherapy may be effective in treatment of patients with metastatic GCT with MT, particularly tumors which express PLAP in the MT element, although this disease entity has traditionally been considered to be chemoresistant.

Details

ISSN :
21923183
Volume :
1
Database :
OpenAIRE
Journal :
International Cancer Conference Journal
Accession number :
edsair.doi...........67ce30d71996e28a8ac4beba5097c630
Full Text :
https://doi.org/10.1007/s13691-011-0010-1