Real-time assessment of tumor-induced by DMBA in mice model guided by swept-source optical coherence tomography

To better understand any tumor, first, we need to know the characteristic features. The tumor microenvironment is that the signature helps us know the dermatological condition for biopsy. Some traditional optical imaging methods have restricted properties to visualize shallow skin highlights, and boundary data is missing to identify pathophysiology relationships of skin infections. Here, we illustrate a swept-source optical coherence tomography (SSOCT) technique that non-invasively visualizes (in-vivo) the tissue micro-structure/neoplastic changes during tumor development as optical biopsy in real-time with pathophysiological correlations in the mice model. To further validate the current study, we perform the corresponding histopathology (ex-vivo) of that tumor region. Furthermore, the scattering coefficient and the optical penetration depth analysis prove that SSOCT imaging can provide detailed findings and treatment in dermatology.