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Novel inhibitors of nicotinamide phosphoribosyl transferase and their evaluation in combination with bortezomib
- Source :
- Journal of Clinical Oncology. 32:e19566-e19566
- Publication Year :
- 2014
- Publisher :
- American Society of Clinical Oncology (ASCO), 2014.
-
Abstract
- e19566 Background: Nicotinamide phosphoribosyl transferase (NAMPT) is the enzyme that catalyzes the rate limiting step in the salvage pathway of Nicotinamide Adenine Dinucleotide (NAD) biosynthesis...
- Subjects :
- chemistry.chemical_classification
endocrine system
Cancer Research
Nicotinamide
business.industry
Bortezomib
Nicotinamide adenine dinucleotide
Rate-determining step
enzymes and coenzymes (carbohydrates)
chemistry.chemical_compound
Enzyme
Oncology
Biochemistry
chemistry
Biosynthesis
Medicine
heterocyclic compounds
NAD+ kinase
business
Nucleotide salvage
medicine.drug
Subjects
Details
- ISSN :
- 15277755 and 0732183X
- Volume :
- 32
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Oncology
- Accession number :
- edsair.doi...........6890341ed2de7a1192cd1f706c505c30
- Full Text :
- https://doi.org/10.1200/jco.2014.32.15_suppl.e19566