Single-Cell Profiling of CD8+ T Cells in Acute Myeloid Leukemia Reveals a Continuous Spectrum of Differentiation and Clonal Hyperexpansion

Authors :: Poonam N. Desai
Bofei Wang
Andre Fonseca
Pamella Borges
Fatima Zahra. Jelloul
Patrick K. Reville
Eric Lee
Christopher Ly
Akshay Basi
Jessica Root
Natalia Baran
Sean M. Post
Qing Deng
Hanxiao Sun
Arif O. Harmanci
Jared K. Burks
Javier A. Gomez
Courtney D. DiNardo
Naval G. Daver
Gheath Alatrash
Marina Konopleva
Michael R. Green
Dinler A. Antunes
Andrew Futreal
Dapeng Hao
Hussein A. Abbas
Source :: Cancer Immunology Research.
Publication Year :: 2023
Publisher :: American Association for Cancer Research (AACR), 2023.
Abstract: Comprehensive investigation of CD8+ T cells in acute myeloid leukemia (AML) is essential for developing immunotherapeutic strategies beyond immune checkpoint blockade. Herein, we performed single-cell RNA profiling of CD8+ T cells from 3 healthy bone marrow donors and 23 newly diagnosed (NewlyDx) and 8 relapsed/refractory (RelRef) AML patients. Cells co-expressing canonical exhaustion markers formed a cluster constituting

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