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Serial circulating tumor DNA (ctDNA) analysis as a prognostic marker and a real-time indicator of adjuvant chemotherapy (CT) efficacy in stage III colon cancer (CC)
- Source :
- Journal of Clinical Oncology. 36:3516-3516
- Publication Year :
- 2018
- Publisher :
- American Society of Clinical Oncology (ASCO), 2018.
-
Abstract
- 3516Background: Adjuvant CT in stage III CC prevents recurrence by eradicating minimal residual disease (MRD) not visible on imaging. However, many patients (pts) will not have MRD and not all pts with MRD will benefit from standard CT. In this study, we determined (i) if the presence of ctDNA following surgery was predictive of recurrence following CT; (ii) if ctDNA could be used to determine the effectiveness of CT during treatment and (iii) if the presence of ctDNA following CT completion was predictive for later recurrence. Methods: Serial plasma samples from stage III CC pts planned for adjuvant CT were collected post-surgery, during CT and at treatment completion. Somatic mutations in individual tumors were identified via massively parallel sequencing of 15 genes commonly mutated in colorectal cancer. Personalized Safe-SeqS assays to quantify ctDNA in plasma samples were designed. Clinicians were blinded to ctDNA results. Results: 95 pts were enrolled from Nov-2014 to May-2017, median age was 64 yea...
- Subjects :
- 0301 basic medicine
Oncology
Cancer Research
medicine.medical_specialty
Massive parallel sequencing
Colorectal cancer
business.industry
Adjuvant chemotherapy
medicine.medical_treatment
medicine.disease
Minimal residual disease
Stage III Colon Cancer
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
Circulating tumor DNA
030220 oncology & carcinogenesis
Internal medicine
medicine
Stage (cooking)
business
Adjuvant
Subjects
Details
- ISSN :
- 15277755 and 0732183X
- Volume :
- 36
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Oncology
- Accession number :
- edsair.doi...........6982d414ce46a306666579d6d458b7a7