EFFICACY OF ENDOSCOPIC INJECTION THERAPY WITH HSE 3% COMBINED WITH HIGH-DOSE PROTON PUMP INHIBITOR IN PEPTIC ULCER BLEEDING

Background: Peptic ulcer bleeding is one of the common medical emergencies with a high rate of mortality. Endoscopic hemostasis with HSE 3% injection is an effective treatment for patients with peptic ulcer bleeding, helps to save cost and avoid an unnecessary emergency surgery. Objective: To determine the success rate of endoscopic hemostatic with HSE 3% injection in patients with peptic ulcer bleeding. Patients and methods: A prospective, cross sectional study on 41 patients with peptic ulcer bleeding admitted in Can Tho Central General Hospital, from August 2012 to April 2013. All the patients underwent emergency endoscopy for hemostasis by injecting HSE 3% solution, and high- dose PPI use. Results: The rate of Forrest class IA, IB, IIA, IIB was 12.2%, 56.1%, 19.5% and 12.2%, respectively. The rate active bleeding group (Forrest class IA/IB) was 668.3%, while hemostatic group with high risk of rebleeding was 31.7%. The success rate was 92.7%, and the rebleeding rate was 7.3%. Conclusion: Endoscopic HSE 3% injection combined with high- dose PPI is an effective, relatively safe treatment for peptic ulcer bleeding. Key words: peptic ulcer bleeding, HSE, endoscopic hemostasis therapy.