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CEND1 and GJB6 co-expression as a prognostic factor in colorectal cancer

Authors :
Junsong Liu
Dong Ma
Zhan Wang
Rui Chen
Xiangming Che
Yijiang Han
Publication Year :
2021
Publisher :
Research Square Platform LLC, 2021.

Abstract

Background: Perineural invasion is an important mechanism of cancer progression that is not well understood at present. The present study explored the relationship between GJB6, CEND1, and cell-cell communication as regulators of colorectal cancer patient survival and clinicopathological findings.Method: Immunohistochemical staining was performed to assess CEND1 and GJB6 expression levels in CRC patient samples, while survival outcomes were assessed using Kaplan-Meier curves and log-rank tests.Results: Elevated CEND1 expression was associated with tumor location, poor differentiation, and perineural invasion, while GJB6 expression was positively correlated with TNM stage, distant metastasis, and perineural invasion. In addition, GJB6 and CEND1 protein levels were correlated with one another in CRC patient tissues, and high expression of both of these proteins was associated with a higher risk of perineural invasion. CEND1+/GJB6+ status was also associated with poorer patient survival, highlighting both of these proteins as prognostic biomarkers in CRC patients.Conclusion: Elevated levels of CEND1 and GJB6 are independent predictors of poorer CRC patient prognosis.

Details

Database :
OpenAIRE
Accession number :
edsair.doi...........6a45cad0fe35445589d5828dbc3f32dc
Full Text :
https://doi.org/10.21203/rs.3.rs-709485/v1