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MR Imaging Safety Considerations of Gadolinium-Based Contrast Agents
- Source :
- Magnetic Resonance Imaging Clinics of North America. 28:497-507
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Gadolinium (Gd)-based contrast agents (GBCAs) have revolutionized of MR imaging, enabling physicians to obtain life-saving medical information that often cannot be obtained with unenhanced MR imaging or other imaging modalities. Since regulatory approval in 1988, more than 450 million intravenous GBCA doses have been administered worldwide, with an extremely favorable pharmacologic safety profile. Recent evidence has demonstrated, however, that a small fraction of Gd is retained in human tissues. No direct correlation between Gd retention and clinical effects has been confirmed; however, a subset of patients have attributed various symptoms to GBCA exposure. This review details current knowledge regarding GBCA safety.
- Subjects :
- medicine.medical_specialty
business.industry
Gadolinium
chemistry.chemical_element
Medical information
medicine.disease
Mr imaging
030218 nuclear medicine & medical imaging
Imaging modalities
03 medical and health sciences
Safety profile
0302 clinical medicine
chemistry
Nephrogenic systemic fibrosis
Medicine
Radiology, Nuclear Medicine and imaging
Radiology
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 10649689
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- Magnetic Resonance Imaging Clinics of North America
- Accession number :
- edsair.doi...........6aeeb10ebff645cf9581bc9ec8b58cbc