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A trial of oral corticosteroids for persistent systemic and airway inflammation in severe asthma

Authors :
Kosuke Ito
Keiji Oishi
Tsunahiko Hirano
Ryo Suetake
Syuichiro Ohata
Kazuto Matsunaga
Yoshikazu Yamaji
Nobutaka Edakuni
Source :
Immunity, Inflammation and Disease. 5:261-264
Publication Year :
2017
Publisher :
Wiley, 2017.

Abstract

Introduction The fraction of exhaled nitric oxide (FeNO) and blood eosinophils, markers of local and systemic eosinophilic inflammation, respectively, are increased in asthmatic patients. Little is known concerning the relationship between the FeNO levels and blood eosinophils in asthmatics. Methods Twenty severe asthmatics with persistent FeNO elevation (≥40 ppb) and blood eosinophilia (≥3%) despite maintenance therapy including high-daily-dose inhaled corticosteroids were analyzed. We investigated the response of FeNO and blood eosinophils to systemic corticosteroids treatment and the change in Asthma Control Questionnaire (ACQ) according to differences in the response of FeNO and blood eosinophils to steroid. Results The changes in blood eosinophils were not correlated with the changes in FeNO levels by systemic steroid treatment (r = 0.37, P = 0.11). 50% of the subjects showed both ≥20% reductions in FeNO levels and blood eosinophils. There were significant differences in the ACQ score between the steroid response group and poor response group (P

Details

ISSN :
20504527
Volume :
5
Database :
OpenAIRE
Journal :
Immunity, Inflammation and Disease
Accession number :
edsair.doi...........6b018a0f2a72c795d2b7d99ab518ce77