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A trial of oral corticosteroids for persistent systemic and airway inflammation in severe asthma
- Source :
- Immunity, Inflammation and Disease. 5:261-264
- Publication Year :
- 2017
- Publisher :
- Wiley, 2017.
-
Abstract
- Introduction The fraction of exhaled nitric oxide (FeNO) and blood eosinophils, markers of local and systemic eosinophilic inflammation, respectively, are increased in asthmatic patients. Little is known concerning the relationship between the FeNO levels and blood eosinophils in asthmatics. Methods Twenty severe asthmatics with persistent FeNO elevation (≥40 ppb) and blood eosinophilia (≥3%) despite maintenance therapy including high-daily-dose inhaled corticosteroids were analyzed. We investigated the response of FeNO and blood eosinophils to systemic corticosteroids treatment and the change in Asthma Control Questionnaire (ACQ) according to differences in the response of FeNO and blood eosinophils to steroid. Results The changes in blood eosinophils were not correlated with the changes in FeNO levels by systemic steroid treatment (r = 0.37, P = 0.11). 50% of the subjects showed both ≥20% reductions in FeNO levels and blood eosinophils. There were significant differences in the ACQ score between the steroid response group and poor response group (P
- Subjects :
- 0301 basic medicine
business.industry
Severe asthma
Immunology
Airway inflammation
respiratory system
medicine.disease
respiratory tract diseases
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
030228 respiratory system
Maintenance therapy
Asthma Control Questionnaire
Exhaled nitric oxide
medicine
Blood eosinophils
Immunology and Allergy
Eosinophilia
medicine.symptom
business
Asthma
Subjects
Details
- ISSN :
- 20504527
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- Immunity, Inflammation and Disease
- Accession number :
- edsair.doi...........6b018a0f2a72c795d2b7d99ab518ce77