Investigation of the antioxidant characteristics of a new tryptamine derivative of securinine and its influence on seizure activity in the brain in experimental epilepsy

We studied the mechanisms of the antioxidant activity of a tryptamine derivative of securinine (TDS) and its influence on the dynamics of seizure activity in various models of experimental epilepsy. We found that the new TDS, which possesses an antioxidant and a chelating effect, has anticonvulsant action in lithium-pilocarpine-induced epilepsy and may be of interest as a potential scaffold for the development of new neuroprotective anticonvulsant drugs.