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Intrabacterial Metabolism Obscures the Successful Prediction of an InhA Inhibitor of Mycobacterium tuberculosis

Authors :
Shao-Gang Li
Alexander L. Perryman
Alex Lemenze
Sean Ekins
Steve D. Paget
Pradeep Kumar
Xin Wang
Thomas P. Stratton
Joel S. Freundlich
Arthur J. Olson
Source :
ACS Infectious Diseases. 5:2148-2163
Publication Year :
2019
Publisher :
American Chemical Society (ACS), 2019.

Abstract

Tuberculosis, caused by Mycobacterium tuberculosis (M. tuberculosis), kills 1.6 million people annually. To bridge the gap between structure- and cell-based drug discovery strategies, we are pionee...

Details

ISSN :
23738227
Volume :
5
Database :
OpenAIRE
Journal :
ACS Infectious Diseases
Accession number :
edsair.doi...........6b6e3505194ba3afaeb6a2674ce9ff0e
Full Text :
https://doi.org/10.1021/acsinfecdis.9b00295