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Imlifidase as a Potential Treatment for Antibody-Mediated Rejection
- Source :
- Current Transplantation Reports. 8:157-161
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Antibody-mediated rejection (ABMR) is implicated as the leading cause of late kidney allograft failure. Current therapies inadequately control the antibody response and persistent donor-specific antibodies lead to chronic ABMR and allograft failure. Imlifidase is an IgG endopeptidase derived from Streptococcus pyogenes that cleaves human IgG into F(ab’)2 and Fc fragments, thereby protecting against complement-dependent cytotoxicity and antibody-dependent cellular cytotoxicity. Favorable outcomes with its use for desensitization in HLA-incompatible kidney transplantation have engendered interest in its use for ABMR. The experiences with imlifidase for a variety of antibody-mediated diseases, including anti-glomerular basement membrane disease, thrombotic thrombocytopenic purpura, and desensitization in HLA-incompatible kidney transplantation, are reviewed to provide a rationale for using imlifidase to treat ABMR in kidney transplantation. Imlifidase is currently being evaluated in comparison to plasmapheresis in a clinical trial and is a potential therapy for ABMR in kidney transplantation.
- Subjects :
- Transplantation
Kidney
Hepatology
biology
business.industry
medicine.medical_treatment
Immunology
Thrombotic thrombocytopenic purpura
Disease
medicine.disease
medicine.disease_cause
medicine.anatomical_structure
Nephrology
Streptococcus pyogenes
biology.protein
Medicine
Surgery
Plasmapheresis
Antibody
business
Kidney transplantation
Desensitization (medicine)
Subjects
Details
- ISSN :
- 21963029
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- Current Transplantation Reports
- Accession number :
- edsair.doi...........6c983747a85c61e30d5290cb4a85f6a2