Molecularly Imprinted Polymers Coupled with Surface-Enhanced Raman Spectroscopy to Detect Chemical Hazards in Foods

Preparation of molecularly imprinted polymers coupled with surface-enhanced Raman spectroscopy (MIP-SERS) sensor and its application in detecting chemical hazards in food matrices are described. Sample cleaning is achieved by molecularly imprinted solid-phase extraction (MISPE), and target molecules are detected by SERS. Procedures of MIP synthesis, MISPE preparation, SERS substrate preparation, spectral collection, data analysis, and food analysis application are described.