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Rational design of class I MHC ligands
- Source :
- AIP Conference Proceedings.
- Publication Year :
- 1995
- Publisher :
- AIP, 1995.
-
Abstract
- From the knowledge of the three‐dimensional structure of a class I MHC protein, several non natural peptides were designed in order to either optimize the interactions of one secondary anchor amino acid with its HLA binding pocket or to substitute the non interacting part with spacer residues. All peptides were synthesized and tested for binding to the class I MHC protein in an in vitro reconstitution assay. As predicted, the non natural peptides present an enhanced binding to the HLA‐B27 molecule with respect to their natural parent peptides. This study constitutes the first step towards the rational design of non peptidic MHC ligands that should be very promising tools for the selective immunotherapy of autoimmune diseases.
Details
- ISSN :
- 0094243X
- Database :
- OpenAIRE
- Journal :
- AIP Conference Proceedings
- Accession number :
- edsair.doi...........6cd740bc009c86aae8e8384ab64af07d
- Full Text :
- https://doi.org/10.1063/1.47772