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Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution
Authors :
Justice, Anne E Karaderi, Tugce Highland, Heather M Young, Kristin L Graff, Mariaelisa Lu, Yingchang Turcot, Valérie Auer, Paul L Fine, Rebecca S Guo, Xiuqing Schurmann, Claudia Lempradl, Adelheid Marouli, Eirini Mahajan, Anubha Winkler, Thomas W Locke, Adam E Medina-Gomez, Carolina Esko, Tõnu Vedantam, Sailaja Giri, Ayush Lo, Ken Sin Alfred, Tamuno Mudgal, Poorva Ng, Maggie CY Heard-Costa, Nancy L Feitosa, Mary F Manning, Alisa K Willems, Sara M Sivapalaratnam, Suthesh Abecasis, Goncalo Alam, Dewan S Allison, Matthew Amouyel, Philippe Arzumanyan, Zorayr Balkau, Beverley Bastarache, Lisa Bergmann, Sven Bielak, Lawrence F Blüher, Matthias Boehnke, Michael Boeing, Heiner Boerwinkle, Eric Böger, Carsten A Bork-Jensen, Jette Bottinger, Erwin P Bowden, Donald W Brandslund, Ivan Broer, Linda Burt, Amber A Butterworth, Adam S Caulfield, Mark J Cesana, Giancarlo Chambers, John C Chasman, Daniel I Chen, Yii-Der Ida Chowdhury, Rajiv Christensen, Cramer Chu, Audrey Y Collins, Francis S Cook, James P Cox, Amanda J Crosslin, David S Danesh, John De Bakker, Paul IW Denus, Simon De Mutsert, Renée De Dedoussis, George Demerath, Ellen W Dennis, Joe G Denny, Josh C Di Angelantonio, Emanuele Dörr, Marcus Drenos, Fotios Dubé, Marie-Pierre Dunning, Alison M Easton, Douglas F Elliott, Paul Evangelou, Evangelos Farmaki, Aliki-Eleni Feng, Shuang Ferrannini, Ele Ferrieres, Jean Florez, Jose C Fornage, Myriam Fox, Caroline S Franks, Paul W Friedrich, Nele Gan, Wei Gandin, Ilaria Gasparini, Paolo Giedraitis, Vilmantas Girotto, Giorgia Gorski, Mathias Grallert, Harald Grarup, Niels Grove, Megan L Gustafsson, Stefan Haessler, Jeff Hansen, Torben Hattersley, Andrew T Hayward, Caroline Heid, Iris M Holmen, Oddgeir L Hovingh, G Kees Howson, Joanna MM Hu, Yao Hung, Yi-Jen Hveem, Kristian Ikram, M Arfan Ingelsson, Erik Jackson, Anne U Jarvik, Gail P Jia, Yucheng Jørgensen, Torben Jousilahti, Pekka Justesen, Johanne M Kahali, Bratati Karaleftheri, Maria Kardia, Sharon LR Karpe, Fredrik Kee, Frank Kitajima, Hidetoshi Komulainen, Pirjo Kooner, Jaspal S Kovacs, Peter Krämer, Bernhard K Kuulasmaa, Kari Kuusisto, Johanna Laakso, Markku Lakka, Timo A Lamparter, David Lange, Leslie A Langenberg, Claudia Larson, Eric B Lee, Nanette R Lee, Wen-Jane Lehtimäki, Terho Lewis, Cora E Li, Huaixing Li, Jin Li-Gao, Ruifang Lin, Li-An Lin, Xu Lind, Lars Lindström, Jaana Linneberg, Allan Liu, Ching-Ti Liu, Dajiang J Luan, Jian'an Lyytikäinen, Leo-Pekka MacGregor, Stuart Mägi, Reedik Männistö, Satu Marenne, Gaëlle Marten, Jonathan Masca, Nicholas GD McCarthy, Mark I Meidtner, Karina Mihailov, Evelin Moilanen, Leena Moitry, Marie Mook-Kanamori, Dennis O Morgan, Anna Morris, Andrew P Müller-Nurasyid, Martina Munroe, Patricia B Narisu, Narisu Nelson, Christopher P Neville, Matt Ntalla, Ioanna O'Connell, Jeffrey R Owen, Katharine R Pedersen, Oluf Peloso, Gina M Pennell, Craig E Perola, Markus Perry, James A Perry, John RB Pers, Tune H Ewing, Ailith Polasek, Ozren Raitakari, Olli T Rasheed, Asif Raulerson, Chelsea K Rauramaa, Rainer Reilly, Dermot F Reiner, Alex P Ridker, Paul M Rivas, Manuel A Robertson, Neil R Robino, Antonietta Rudan, Igor Ruth, Katherine S Saleheen, Danish Salomaa, Veikko Samani, Nilesh J Schreiner, Pamela J Schulze, Matthias B Scott, Robert A Segura-Lepe, Marcelo Sim, Xueling Slater, Andrew J Small, Kerrin S Smith, Blair H Smith, Jennifer A Southam, Lorraine Spector, Timothy D Speliotes, Elizabeth K Stefansson, Kari Steinthorsdottir, Valgerdur Stirrups, Kathleen E Strauch, Konstantin Stringham, Heather M Stumvoll, Michael Sun, Liang Surendran, Praveen Swart, Karin MA Tardif, Jean-Claude Taylor, Kent D Teumer, Alexander Thompson, Deborah J Thorleifsson, Gudmar Thorsteinsdottir, Unnur Thuesen, Betina H Tönjes, Anke Torres, Mina Tsafantakis, Emmanouil Tuomilehto, Jaakko Uitterlinden, André G Uusitupa, Matti Van Duijn, Cornelia M Vanhala, Mauno Varma, Rohit Vermeulen, Sita H Vestergaard, Henrik Vitart, Veronique Vogt, Thomas F Vuckovic, Dragana Wagenknecht, Lynne E Walker, Mark Wallentin, Lars Wang, Feijie Wang, Carol A Wang, Shuai Wareham, Nicholas J Warren, Helen R Waterworth, Dawn M Wessel, Jennifer White, Harvey D Willer, Cristen J Wilson, James G Wood, Andrew R Wu, Ying Yaghootkar, Hanieh Yao, Jie Yerges-Armstrong, Laura M Young, Robin Zeggini, Eleftheria Zhan, Xiaowei Zhang, Weihua Zhao, Jing Hua Zhao, Wei Zheng, He Zhou, Wei Zillikens, M Carola Rivadeneira, Fernando Borecki, Ingrid B Pospisilik, J Andrew Deloukas, Panos Frayling, Timothy M Lettre, Guillaume Mohlke, Karen L Rotter, Jerome I Kutalik, Zoltán Hirschhorn, Joel N Cupples, L Adrienne Loos, Ruth JF North, Kari E Lindgren, Cecilia M CHD Exome+ Consortium Cohorts For Heart And Aging Research In Genomic Epidemiology (CHARGE) Consortium EPIC-CVD Consortium ExomeBP Consortium Global Lipids Genetic Consortium GoT2D Genes Consortium InterAct ReproGen Consortium T2D-Genes Consortium MAGIC Investigators
Publisher :
Springer Science and Business Media LLC
Abstract
Body-fat distribution is a risk factor for adverse cardiovascular health consequences. We analyzed the association of body-fat distribution, assessed by waist-to-hip ratio adjusted for body mass index, with 228,985 predicted coding and splice site variants available on exome arrays in up to 344,369 individuals from five major ancestries (discovery) and 132,177 European-ancestry individuals (validation). We identified 15 common (minor allele frequency, MAF ≥5%) and nine low-frequency or rare (MAF
Details
Database :
OpenAIRE
Accession number :
edsair.doi...........6d155e55cab6201548d4294b6f7a099b