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Transplantable Animal Studies and Whole-Body Optical Imaging in Prostate Carcinoma
- Source :
- Methods in Molecular Biology ISBN: 9781493978434
- Publication Year :
- 2018
- Publisher :
- Springer New York, 2018.
-
Abstract
- Current treatments of advanced prostate cancer only marginally increase overall survival and can be regarded as predominantly palliative. Hence, there is an urgent need for novel therapeutic strategies for the treatment of primary tumors and, more importantly perhaps, for the prevention of tumor progression and metastasis formation. Clinically relevant preclinical models are therefore urgently needed. An ideal, clinically relevant preclinical model would mimic the genetic and phenotypic changes that occur at the different stages of human prostate cancer progression and subsequent metastasis. In this chapter, transplantable xenograft prostate cancer models are described, in which human prostate cancer cells are transplanted into host animals (e.g., immune-deficient mice). Cancer cells can be administered to the small laboratory animals in various ways, including inoculation of the prostate tumor cells subcutaneously, at the anatomical site of origin (orthotopically), or at the metastatic site. In addition, we describe imaging methods suitable for small laboratory animals with emphasis on optical imaging (bioluminescence and fluorescence).
- Subjects :
- 0301 basic medicine
business.industry
Cancer
medicine.disease
Metastasis
03 medical and health sciences
Prostate cancer
030104 developmental biology
0302 clinical medicine
Optical imaging
medicine.anatomical_structure
Prostate
Tumor progression
030220 oncology & carcinogenesis
Cancer cell
medicine
Cancer research
Animal studies
business
Subjects
Details
- ISBN :
- 978-1-4939-7843-4
- ISBNs :
- 9781493978434
- Database :
- OpenAIRE
- Journal :
- Methods in Molecular Biology ISBN: 9781493978434
- Accession number :
- edsair.doi...........6e13fb9fd219d7a2065aa0700c85862a