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DABCO-Promoted Decarboxylative Acylation: Synthesis of α-Keto and α,β-Unsaturated Amides or Esters
- Source :
- Asian Journal of Organic Chemistry. 6:305-312
- Publication Year :
- 2017
- Publisher :
- Wiley, 2017.
-
Abstract
- 1,4-Diazabicyclo[2.2.2]octane (DABCO) was found to be an effective reagent for decarboxylative acylation of carboxylic acids with carbamic chlorides or alkyl carbonochloridates. In the absence of metal catalyst, carboxylic acids including α-ketocarboxylic, cinnamic and arylpropiolic acids underwent the decarboxylative acylation smoothly to afford a variety of α-keto (or α,β-unsaturated) amides and esters in good to excellent yields.
- Subjects :
- chemistry.chemical_classification
010405 organic chemistry
Decarboxylation
Carboxylic acid
Organic Chemistry
DABCO
010402 general chemistry
01 natural sciences
0104 chemical sciences
Acylation
chemistry.chemical_compound
chemistry
Reagent
Organic chemistry
lipids (amino acids, peptides, and proteins)
Metal catalyst
Alkyl
Octane
Subjects
Details
- ISSN :
- 21935807
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- Asian Journal of Organic Chemistry
- Accession number :
- edsair.doi...........6e541748065eb4eba8092ce524efc007