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Synthesis and Antibacterial Evaluation of Cu(II), Co(II), and Mn(II) Complexes with Schiff Bases Derived from 5-Aminosalicylic Acid and o-Vanillin
- Source :
- Russian Journal of General Chemistry. 89:1691-1695
- Publication Year :
- 2019
- Publisher :
- Pleiades Publishing Ltd, 2019.
-
Abstract
- The current study is devoted to the synthesis of Schiff base ligand, HL, by condensation of 5-aminosalicylic acid with o-vanillin, followed by preparing its Cu(II), Co(II), Mn(II), and Zn(II) complexes, and their characterization. The Schiff base behaves as a bidentate ligand which forms tetrahedral complexes with Cu(II) and Zn(II), unlike Co(II) and Mn(II) that give octahedral complexes. The Schiff base ligand and its complexes with Cu2+, Co2+, Mn2+, and Zn2+ exhibit considerable antibacterial activity against some drug resistant reference strains and local isolates of S. aureus, E. Coli, P. aersginosa. Overall, the metal complexes exhibit more potent antibacterial activity than the ligand HL alone.
- Subjects :
- Schiff base
Aminosalicylic acid
010405 organic chemistry
Ligand
O-vanillin
General Chemistry
010402 general chemistry
01 natural sciences
Medicinal chemistry
0104 chemical sciences
Metal
chemistry.chemical_compound
chemistry
Octahedron
visual_art
visual_art.visual_art_medium
Antibacterial activity
Subjects
Details
- ISSN :
- 16083350 and 10703632
- Volume :
- 89
- Database :
- OpenAIRE
- Journal :
- Russian Journal of General Chemistry
- Accession number :
- edsair.doi...........6f1188325b79d4778436f325b9e88b58