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Bayesian diagnostic analysis for quantitative traitlocimapping
- Source :
- Statistical Methods in Medical Research. 29:2238-2249
- Publication Year :
- 2019
- Publisher :
- SAGE Publications, 2019.
-
Abstract
- QTL mapping is an important tool for identifying regions in chromosomes which are relevant to explain a response of interest. It is a special case of the regression model where an unknown number of missing (non-observable) covariates is involved leading to a complex variable selection procedure. Although several methods have been proposed to identify QTLs and to estimate parameters in the associated model, minimum attention has been devoted to the estimated model adequacy. In this paper, we present an overview of a few methods for residual and diagnostic analysis in the context of Bayesian regression modeling and adapt them to work with QTL mapping. The motivation of this study is to identify QTLs associated with the blood pressure of F2 rats and check the fitted model adequacy.
- Subjects :
- Statistics and Probability
0303 health sciences
Epidemiology
Bayesian probability
food and beverages
Regression analysis
Computational biology
Quantitative trait locus
Biology
Residual
01 natural sciences
010104 statistics & probability
03 medical and health sciences
Health Information Management
Diagnostic analysis
0101 mathematics
030304 developmental biology
Subjects
Details
- ISSN :
- 14770334 and 09622802
- Volume :
- 29
- Database :
- OpenAIRE
- Journal :
- Statistical Methods in Medical Research
- Accession number :
- edsair.doi...........6f1da29197b010216330725ad15fb2be
- Full Text :
- https://doi.org/10.1177/0962280219888950