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Bayesian diagnostic analysis for quantitative traitlocimapping

Authors :
Júlia Maria Pavan Soler
Luis Aparecido Milan
Daiane Aparecida Zuanetti
José Eduardo Krieger
Source :
Statistical Methods in Medical Research. 29:2238-2249
Publication Year :
2019
Publisher :
SAGE Publications, 2019.

Abstract

QTL mapping is an important tool for identifying regions in chromosomes which are relevant to explain a response of interest. It is a special case of the regression model where an unknown number of missing (non-observable) covariates is involved leading to a complex variable selection procedure. Although several methods have been proposed to identify QTLs and to estimate parameters in the associated model, minimum attention has been devoted to the estimated model adequacy. In this paper, we present an overview of a few methods for residual and diagnostic analysis in the context of Bayesian regression modeling and adapt them to work with QTL mapping. The motivation of this study is to identify QTLs associated with the blood pressure of F2 rats and check the fitted model adequacy.

Details

ISSN :
14770334 and 09622802
Volume :
29
Database :
OpenAIRE
Journal :
Statistical Methods in Medical Research
Accession number :
edsair.doi...........6f1da29197b010216330725ad15fb2be
Full Text :
https://doi.org/10.1177/0962280219888950