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Zebrafish Tumor Graft Transplantation to Grow Tumors In Vivo That Engraft Poorly as Single Cell Suspensions
- Source :
- Zebrafish. 18:293-296
- Publication Year :
- 2021
- Publisher :
- Mary Ann Liebert Inc, 2021.
-
Abstract
- Angiosarcoma is a clinically aggressive tumor with a high rate of mortality. It can arise in vascular or lymphatic tissues, involve any part of the body, and aggressively spread locally or metastasize. Angiosarcomas spontaneously develop in the tp53 deleted (tp53del/del) zebrafish mutant. However, established protocols for tumor dissection and transplantation of single cell suspensions of angiosarcoma tumors result in inferior implantation rates. To resolve these complications, we developed a new tumor grafting technique for engraftment of angiosarcoma and similar tumors in zebrafish, which maintains the tumor microenvironment and has superior rates of engraftment.
- Subjects :
- 0303 health sciences
Tumor microenvironment
Cell
Biology
biology.organism_classification
digestive system diseases
Transplantation
03 medical and health sciences
Dissection
0302 clinical medicine
medicine.anatomical_structure
In vivo
medicine
Cancer research
Animal Science and Zoology
Angiosarcoma
neoplasms
Zebrafish
030217 neurology & neurosurgery
030304 developmental biology
Developmental Biology
Tumor Graft
Subjects
Details
- ISSN :
- 15578542 and 15458547
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Zebrafish
- Accession number :
- edsair.doi...........70485ab97281fc2565bf001f73ce68a1
- Full Text :
- https://doi.org/10.1089/zeb.2021.0006