Role of cyclooxygenase-2 in inflammation

ARACHIDONATE 12-LIPOXYGENASES: THEIR POSSIBLE PHYSIOLOGICAL AND PATHOLOGICAL ROLES S. Yamamoto~, N. Uedal, K. Yamamotol, 3". Tokunaga2, E. Shirakawa2, H. Shinkai2, M. Ogawa 3, T. Sato 3, I. Kudo 3, K. Inoue 3, H. Takizawa 3, T. Nagano 3, M. Hirobe3, N. Matsuki3, H. Saito 3 1) Department of Biochemistry, Tokushima University, School of Medicine, Tokushima 770, Japan 2) Japan Tobacco Inc., Central Pharmaceutical Research Institute, Takatsuki, Osaka 569, Japan 3) Faculty of Pharmaceudcal Sciences, the University of Tokyo, Tokyo 113, Japan