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Biomarkers of inflammation and oxidative stress in smokers and severe chronic obstructive pulmonary disease patients
- Source :
- IP Indian Journal of Immunology and Respiratory Medicine. 5:173-180
- Publication Year :
- 2020
- Publisher :
- IP Innovative Publication Pvt Ltd, 2020.
-
Abstract
- Identification of biomarkers for the novel therapeutics targets of Chronic obstructive pulmonary disease (COPD) is an important area of current research. In this study, the level of inflammatory cytokines was investigated and correlated these levels with erythrocytic antioxidant activities in COPD patients with smokers and without smokers and parameters of severity.Plasma levels of Interleukin (IL)-6, IL-8 and IL-10 concentrations were assayed by means of Enzyme-linked Immunosorbent Assay (ELISA) and erythrocytic glutathione-s-transferase (GST) and glutathione peroxidase (GPx) activities were estimated by spectrophotometric method.Both IL-6 and IL-8 plasma levels showed a statistically significantly higher in COPD patients as compared to healthy controls (p0.05) and GPx activities (r= - 0.080, p>0.05). Similarly IL-8 was also found negative association with GST (r= - 0.260, p>0.05) and GPx activities (r= - 0.268, p>0.05). Whereas, a significant positive association was observed between IL-10 and erythrocytic GST (r= 0.494, p In conclusion, Plasma levels of inflammatory cytokines IL-6 and IL-8 are related with severity of COPD and IL-10 and oxidative stress markers GST and GPx are co-dependent and strongly interrelated processes and may be used as a potential marker for the evaluation of COPD.
- Subjects :
- medicine.medical_specialty
Antioxidant
medicine.medical_treatment
Inflammation
medicine.disease_cause
Proinflammatory cytokine
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
General Environmental Science
chemistry.chemical_classification
COPD
business.industry
Glutathione peroxidase
General Engineering
Interleukin
medicine.disease
Endocrinology
Pulmonology
030228 respiratory system
chemistry
General Earth and Planetary Sciences
medicine.symptom
business
Oxidative stress
030215 immunology
Subjects
Details
- ISSN :
- 25814222 and 25814214
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- IP Indian Journal of Immunology and Respiratory Medicine
- Accession number :
- edsair.doi...........7085808a8507e66cf036d5d3e1e02367