Identification of a sulfated tetrasaccharide with heparin-like antiproliferative activity

Investigation of the smooth muscle cell antiproliferative activities of Trestatin A sulfate substructures showed that a sulfated pentasaccharide is required to maintain a heparin-like effect. The modification of one glycosidic bond led to a synthetically readily available tetrasaccharide, namely sulfated β-maltosyl trehalose12, with similar antiproliferative but devoid of anticoagulant acitivity.