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Comparison of the Hydroxylase Inhibitor Dimethyloxalylglycine and the Iron Chelator Deferoxamine in Diabetic and Aged Wound Healing
- Source :
- Plastic and Reconstructive Surgery. 139:695e-706e
- Publication Year :
- 2017
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2017.
-
Abstract
- Background:A hallmark of diabetes mellitus is the breakdown of almost every reparative process in the human body, leading to critical impairments of wound healing. Stabilization and activity of the transcription factor hypoxia-inducible factor (HIF)-1α is impaired in diabetes, leading to deficits in
- Subjects :
- 0301 basic medicine
Iron Chelator
Pathology
medicine.medical_specialty
business.industry
medicine.disease
Deferoxamine
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
Endocrinology
030220 oncology & carcinogenesis
Diabetes mellitus
Internal medicine
medicine
Surgery
Wound healing
business
Transcription factor
medicine.drug
Subjects
Details
- ISSN :
- 00321052
- Volume :
- 139
- Database :
- OpenAIRE
- Journal :
- Plastic and Reconstructive Surgery
- Accession number :
- edsair.doi...........70b2e0d703e5bcd36f26b305b29821b0
- Full Text :
- https://doi.org/10.1097/prs.0000000000003072