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HUMAN LYMPHOID CELLS EXPRESS EPITHELIAL MEMBRANE ANTIGEN
HUMAN LYMPHOID CELLS EXPRESS EPITHELIAL MEMBRANE ANTIGEN
- Source :
- The Lancet. 324:1124-1129
- Publication Year :
- 1984
- Publisher :
- Elsevier BV, 1984.
-
Abstract
- Epithelial membrane antigen (EMA) is generally assumed to be expressed only on epithelial cells. However, EMA was also found on reactive and neoplastic plasma cells, on some non-Hodgkin's lymphomas (particularly cases of T-cell lymphoma and "malignant histiocytosis"), and on Reed-Sternberg cells in cases of lymphocyte-predominant Hodgkin's disease. EMA was also induced on normal blood lymphocytes by exposure to human T-lymphotropic virus type II or phytohaemagglutinin. The specificity of these aberrant reactions was confirmed by the use of three different monoclonal anti-EMA antibodies (E29, HMFG2, and LICR.LON/M8), and by showing that EMA in lymphoid tissue is similar in molecular weight to EMA in human milk. These results indicate that additional anti-epithelial antibodies (eg, anti-cytokeratins) should be used in conjunction with anti-EMA for tumour diagnosis.
Details
- ISSN :
- 01406736
- Volume :
- 324
- Database :
- OpenAIRE
- Journal :
- The Lancet
- Accession number :
- edsair.doi...........71058ed3cc6ff87872446f1e2956c7fd
- Full Text :
- https://doi.org/10.1016/s0140-6736(84)91558-7