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Factors related to lithium blood concentrations in Chinese Han patients with bipolar disorder
- Source :
- Neuropsychiatric Disease and Treatment. 15:1929-1937
- Publication Year :
- 2019
- Publisher :
- Informa UK Limited, 2019.
-
Abstract
- Background: The goal of this study was to identify the physiological factors related to the blood concentration of lithium in Chinese Han patients with bipolar disorder (BD). Materials and methods: A total of 186 Chinese Han patients with BD were assessed. Patients were recruited from the Anhui Mental Health Center. The concentrations of serum lithium were measured by a Dimension RxL Max biochemistry analyzer. Physiological factors, including body weight, body mass index (BMI), and routine laboratory parameters, were collected. Relationships between the serum lithium concentration and relevant clinical data were analyzed by Pearson correlation tests, and the independent relationships were determined by multivariate linear regression analysis. Results: Pearson correlation analysis showed that serum lithium concentrations were positively correlated with creatinine concentrations (r=0.147, P=0.046), Mg2+ concentrations (r=0.151, P=0.04), and the percentage of neutrophils (r=0.178, P=0.015) and negatively correlated with high-density lipoprotein (HDL) concentrations (r=-0.142, P=0.05), apolipoprotein A1 concentrations (r=-0.169, P=0.02), and Na+ concentrations (r=-0.148, P=0.046) in 186 patients with BD. Furthermore, multivariate linear regression analysis showed that serum lithium concentrations were negatively associated with Na+ concentrations and positively associated with the percentage of neutrophils. Conclusion: These results suggest that physiological factors, including creatinine, HDL, apolipoprotein A1, Na+, and Mg2+ concentrations and percentage of neutrophils, might be related to serum lithium concentrations and provide a basis for parameter selection of lithium population pharmacokinetics in Chinese Han patients with BD.
- Subjects :
- medicine.medical_specialty
Creatinine
biology
Lithium (medication)
business.industry
medicine.disease
030227 psychiatry
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Endocrinology
High-density lipoprotein
chemistry
Internal medicine
Bayesian multivariate linear regression
medicine
biology.protein
Apolipoprotein A1
Bipolar disorder
business
Body mass index
030217 neurology & neurosurgery
Lipoprotein
medicine.drug
Subjects
Details
- ISSN :
- 11782021
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- Neuropsychiatric Disease and Treatment
- Accession number :
- edsair.doi...........715692d193cc8e0dc3edc9f9f7fd0f20