P145 Clinical and phenotypic characteristics of Crohn's disease in elderly people: A population-based study

Background : HPI or stool transplant has shown promising results in treatment of Clostridium difficile infection. It has also shown some efficacy in treatment of Ulcerative Colitis and being used as a modality of treatment at some centers outside United States. So far there is no data available about efficacy of this treatment modality. Also there is no data available regarding efficacy & patient's perception about this treatment method. Methods: In this study, we enrolled 16 patients with Ulcerative Colitis established with our Crohn's & Colitis clinic who performed home based HPI for their disease. A short telephone survey was conducted to understand patients' perception about HPI. Patients were asked to grade effectiveness of their therapy on scale of 1 to 5, 5 being most effective in achieving primary goal. Patient's medical records were reviewed to obtain pre-transplant disease factors such as pre-transplant medications, Lichtiger score. Results: The average age of recipient group was 33+/5 years, while the average age of donor group was 43+/-6 years. Out of 16 patients who performed HPI for their disease, 8 (50%) achieved their primary goal which was to avoid medications or to avoid surgery. Patients were divided into two groups based on scale of effectiveness of treatment. Group 1 (38%) with Patients with score of more than 3 and Group 2 (62%) with patients with score of less than 3. In group 1, average duration of disease was 5 years as compared to 13 years in group 2(p=0.05). In group 1, 60% patients were on steroids prior to transplant as compared to 30% in group 2. 50% patients were on biologics before transplant in group 1 as compared to 30% in group 2. Female: Male (F: M) ratio for recipient in group 1 was 5 as compared to 0.25 in group 2. (p=0.01) F: M ratio for donor in group 1 was 0.2 as compared to 2.3 in group 2 (p=0.03). Average Lichtiger score in group 1 was 8.8 as compared to 3.5 in group 2 (p=0.05). Conclusion: Human Probiotic Infusion helped 50% of patients in achieving their primary goal. Benefits were highest with female recipient and male donors. Patients with more severe disease (evident by higher Lichtiger score and use of steroid/ biologics) have better outcomes in terms of achieving primary goal.