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On the biosynthesis of an inhibitor of the p53/MDM2 interaction
- Source :
- Tetrahedron Letters. 43:1075-1078
- Publication Year :
- 2002
- Publisher :
- Elsevier BV, 2002.
-
Abstract
- The biosynthesis of a fungal secondary metabolite, chlorofusin, which disrupts the interaction between the proteins p53 and MDM2, has been investigated; the acetogenic origin of the chromophore backbone as well as of an aminodecanoic acid residue is demonstrated.
Details
- ISSN :
- 00404039
- Volume :
- 43
- Database :
- OpenAIRE
- Journal :
- Tetrahedron Letters
- Accession number :
- edsair.doi...........71de83f502568c505a01134f28911a96
- Full Text :
- https://doi.org/10.1016/s0040-4039(01)02239-0