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Lectin-binding histochemistry of verruca vulgaris and seborrheic keratosis
- Source :
- ACTA HISTOCHEMICA ET CYTOCHEMICA. 17:399-413
- Publication Year :
- 1984
- Publisher :
- Japan Society of Histochemistry & Cytochemistry, 1984.
-
Abstract
- Sugar residues in the epithelial cells of verruca vulgaris and seborrheic keratosis were demonstrated by the horseradish peroxidase-conjugated lectin methods. The lectins, Con A, RCA-1, UEA-1, DBA, PNA, SBA, and WGA were used to bind specifically to the sugars, Man, Glc, Gal, Fuc, GalNAc, GlcNAc and NANA. The cytochemical distribution of lectin bindings were limited to the cell surface, intercellular materials and basement membrane in the epithelial structures of the lesions. The lectin bindings in the basal layer cells were negative or weak, but increased gradually in upper spinous cells from moderate to strong levels. Vacuolated cells in verruca vulgaris showed positive lectin stainings. The intercellular materials of parakeratinized cells bound lectins differently, but orthokeratinized cells failed to bind lectins. The regional distribution of lectin bindings in stratified squamous epithelia may indicate an expression of keratinocytic stratification as well as in keratinized benign lesions.
- Subjects :
- Basement membrane
Seborrheic keratosis
Pathology
medicine.medical_specialty
Histology
Physiology
Cell
Lectin
Cell Biology
Biology
medicine.disease
Biochemistry
Molecular biology
Pathology and Forensic Medicine
Basal (phylogenetics)
medicine.anatomical_structure
medicine
biology.protein
Immunohistochemistry
Verruca Vulgaris
Intracellular
Subjects
Details
- ISSN :
- 13475800 and 00445991
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- ACTA HISTOCHEMICA ET CYTOCHEMICA
- Accession number :
- edsair.doi...........729a9e52c535caa4eedf4425e9118f8e