Back to Search Start Over

Fatigue in relation to treatment and gonadal function in a population-based sample of 796 testicular cancer survivors 12 and 19 years after treatment

Fatigue in relation to treatment and gonadal function in a population-based sample of 796 testicular cancer survivors 12 and 19 years after treatment

Authors :
Trine Bjoero
Cecilie E. Kiserud
Carl W. Langberg
Torgrim Tandstad
Marianne Brydøy
Hege Sagstuen Haugnes
Mette Sprauten
Jan Oldenburg
Johan Bjerner
Sophie D. Fosså
Milada Cvancarova
Source :
Journal of Clinical Oncology. 32:4564-4564
Publication Year :
2014
Publisher :
American Society of Clinical Oncology (ASCO), 2014.

Abstract

4564 Background: Chronic fatigue (CF) is more prevalent in Testicular Cancer Survivors (TCSs) 12 years after treatment than in the general population (16% versus 10%). CF-related symptoms of emotional, physical and/or cognitive tiredness may be associated with poor gonadal function (low testosterone (T) and/or high Luteinizing Hormone (LH)). In this longitudinal study we assessed the prevalence of CF median 12 (12y) and 19 years (19y) after treatment in relation to applied treatment, age and levels of T and LH. Methods: T and LH levels were retrieved from 796 TCSs who completed fatigue questionnaires median 12y and 19y after treatment and categorized according to quartile thresholds of healthy controls for decadal age groups. Treatment was categorized as surgery (S, n=162), radiotherapy (RT, n=339) or chemotherapy (CT, n= 295). CF was defined according to previously published cut-off levels. Associations between CF and hormone levels, age and treatment were assessed with logistic regression. Results: CF i...

Details

ISSN :
15277755 and 0732183X
Volume :
32
Database :
OpenAIRE
Journal :
Journal of Clinical Oncology
Accession number :
edsair.doi...........72a0fe4e296e563b20ac8aec00116492
Full Text :
https://doi.org/10.1200/jco.2014.32.15_suppl.4564