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Fatigue in relation to treatment and gonadal function in a population-based sample of 796 testicular cancer survivors 12 and 19 years after treatment
Fatigue in relation to treatment and gonadal function in a population-based sample of 796 testicular cancer survivors 12 and 19 years after treatment
- Source :
- Journal of Clinical Oncology. 32:4564-4564
- Publication Year :
- 2014
- Publisher :
- American Society of Clinical Oncology (ASCO), 2014.
-
Abstract
- 4564 Background: Chronic fatigue (CF) is more prevalent in Testicular Cancer Survivors (TCSs) 12 years after treatment than in the general population (16% versus 10%). CF-related symptoms of emotional, physical and/or cognitive tiredness may be associated with poor gonadal function (low testosterone (T) and/or high Luteinizing Hormone (LH)). In this longitudinal study we assessed the prevalence of CF median 12 (12y) and 19 years (19y) after treatment in relation to applied treatment, age and levels of T and LH. Methods: T and LH levels were retrieved from 796 TCSs who completed fatigue questionnaires median 12y and 19y after treatment and categorized according to quartile thresholds of healthy controls for decadal age groups. Treatment was categorized as surgery (S, n=162), radiotherapy (RT, n=339) or chemotherapy (CT, n= 295). CF was defined according to previously published cut-off levels. Associations between CF and hormone levels, age and treatment were assessed with logistic regression. Results: CF i...
- Subjects :
- Cancer Research
medicine.medical_specialty
Longitudinal study
education.field_of_study
business.industry
medicine.medical_treatment
Population
Chronic fatigue
medicine.disease
Logistic regression
Radiation therapy
Oncology
Quartile
Internal medicine
medicine
Luteinizing hormone
business
education
Testicular cancer
Subjects
Details
- ISSN :
- 15277755 and 0732183X
- Volume :
- 32
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Oncology
- Accession number :
- edsair.doi...........72a0fe4e296e563b20ac8aec00116492
- Full Text :
- https://doi.org/10.1200/jco.2014.32.15_suppl.4564