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Cell Replacement Therapy in Acute Stroke: Current State

Authors :
Yossi Gilgun-Sherki
Jonathan Y. Streifler
Source :
Stem Cell and Gene-Based Therapy ISBN: 9781852339791
Publication Year :
2006
Publisher :
Springer London, 2006.

Abstract

western world, resulting in chronic disability in many cases. Although huge efforts have been made in the search for effective treatment, so far results have been quite disappointing. Recently, cell replacement therapy has emerged as an experimental approach aiming to restore brain function, which is impaired in several neurodegenerative diseases, as well as in stroke. Porcine fetal cells, neuronal progenitor cells (NPCs), embryonic stem cells (ESCs), immortalized cell lines, bone marrow stromal cells (BMSCs), and umbilical cord blood cells (UCBCs) have been introduced as potential sources for neuronal cells in experimental and clinical stroke trials. However, limited knowledge about their biology (including long-term safety) and insufficient data regarding several issues such as the preferred stroke type and its severity, specific location of the injection, and the preferred cell type restrict their potential clinical use. Therefore, further research on the molecular mechanisms of stroke, the candidate cell lines for transplantation, and bioengineering strategies, is needed before this technique can be implemented safely and effectively in stroke victims.

Details

ISBN :
978-1-85233-979-1
ISBNs :
9781852339791
Database :
OpenAIRE
Journal :
Stem Cell and Gene-Based Therapy ISBN: 9781852339791
Accession number :
edsair.doi...........72ad2cec23996e8b17f6f2e235fb3732
Full Text :
https://doi.org/10.1007/1-84628-142-3_8