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Cell Replacement Therapy in Acute Stroke: Current State
- Source :
- Stem Cell and Gene-Based Therapy ISBN: 9781852339791
- Publication Year :
- 2006
- Publisher :
- Springer London, 2006.
-
Abstract
- western world, resulting in chronic disability in many cases. Although huge efforts have been made in the search for effective treatment, so far results have been quite disappointing. Recently, cell replacement therapy has emerged as an experimental approach aiming to restore brain function, which is impaired in several neurodegenerative diseases, as well as in stroke. Porcine fetal cells, neuronal progenitor cells (NPCs), embryonic stem cells (ESCs), immortalized cell lines, bone marrow stromal cells (BMSCs), and umbilical cord blood cells (UCBCs) have been introduced as potential sources for neuronal cells in experimental and clinical stroke trials. However, limited knowledge about their biology (including long-term safety) and insufficient data regarding several issues such as the preferred stroke type and its severity, specific location of the injection, and the preferred cell type restrict their potential clinical use. Therefore, further research on the molecular mechanisms of stroke, the candidate cell lines for transplantation, and bioengineering strategies, is needed before this technique can be implemented safely and effectively in stroke victims.
Details
- ISBN :
- 978-1-85233-979-1
- ISBNs :
- 9781852339791
- Database :
- OpenAIRE
- Journal :
- Stem Cell and Gene-Based Therapy ISBN: 9781852339791
- Accession number :
- edsair.doi...........72ad2cec23996e8b17f6f2e235fb3732
- Full Text :
- https://doi.org/10.1007/1-84628-142-3_8