Pilot Data Assessing the Functional Integrity of the Default Network in Adult ADHD with fMRI and sLORETA

Intrinsic functional connectivity within the default mode network (DMN) of the brain has gained growing interest in attention deficit/hyperactivity disorder (ADHD). The DMN is proposed to support such core functions as theory of mind, self-related activities such as autobiographical self, stimulus independent thought, self-projection, self-reference, and introspective processes as well as central features of self-regulation, task compliance, and executive functions. Based on prior data showing that sLORETA and fMRI localize DMN regions with complementary accuracy, we hypothesized that this combination of methods could provide important information about the functional integrity of DMN connectivity with special attention between parietal and medial prefrontal regions. This study was conducted with 6 adults with ADHD and 7 age-similar, nonclinical controls. The present study recorded brain activity using both EEG and fMRI during rest and a Stroop paradigm. For this study only the eyes-opened rest data were ...