Back to Search Start Over

Hypocretins (Orexins): Twenty Years of Dissecting Arousal Circuits

Hypocretins (Orexins): Twenty Years of Dissecting Arousal Circuits

Authors :
Luis de Lecea
Kimberly J. Jennings
Publication Year :
2019
Publisher :
Elsevier, 2019.

Abstract

Twenty years ago, the hypocretins/orexins were independently identified by de Lecea et al. and Sakurai et al. as novel neuropeptides expressed exclusively in the lateral hypothalamus (de Lecea et al., 1998; Sakurai et al., 1998). Although neither paper mentioned sleep, an explosion of research over the intervening twenty years has revealed a critical role for Hcrt in promoting arousal and regulating sleep/wake stability. Moreover, the Hcrt system has proven especially amenable to genetically and anatomically targeted manipulations, facilitating rapid and systematic description of the circuit mechanisms mediating arousal. This chapter will review the evidence revealing Hcrt's role in arousal and the insights gained by using the Hcrt system as a foothold to gain access to arousal circuits.

Details

Database :
OpenAIRE
Accession number :
edsair.doi...........730661c4f683c209ebaa5afad5cc5b80
Full Text :
https://doi.org/10.1016/b978-0-12-813751-2.00001-2