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Urinary and Faecal Excretion of Phenanthrene and Phenanthrols by Rats Following Oral, Intraperitoneal, or Intrapulmonary Application
- Source :
- Polycyclic Aromatic Compounds. 2:39-47
- Publication Year :
- 1991
- Publisher :
- Informa UK Limited, 1991.
-
Abstract
- Excretion of phenanthrene and its metabolites, 1–; 2–; 3–; 4– and 9–OH–phenanthrene after alkaline and acidic saponification of urine and faeces, has been studied in rats following oral, intraperitoneal and intrapulmonary application of phenanthrene. GC and GC/MS methods have been used as analytical techniques. In all cases 1,2-oxidation of phenanthrene was found to be the predominant pathway. Total excretion of 11–18% of the phenanthrene administered by the above routes was observed indicating the presence of water-soluble metabolites other than sulfates and glucuronides. Phenanthrene apparently is suitable for biologically monitoring polycyclic aromatic hydrocarbons. The reasons are: a) the large amounts of phenanthrene and its metabolites excreted in the urine within a period of 3 days following intrapulmonary (1.3%), intraperitoneal (2.9%), or oral (4.1%) administration of phenanthrene, respectively; b) varied metabolites are formed which can reflect qualitatively the regiospecific monooxygen...
Details
- ISSN :
- 15635333 and 10406638
- Volume :
- 2
- Database :
- OpenAIRE
- Journal :
- Polycyclic Aromatic Compounds
- Accession number :
- edsair.doi...........730d1061f957e4582953d719996b3d23