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Ventricular arrhythmias and implantable cardioverter-defibrillator therapy in women: a propensity score-matched analysis
- Source :
- EP Europace. 24
- Publication Year :
- 2022
- Publisher :
- Oxford University Press (OUP), 2022.
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Abstract
- Funding Acknowledgements Type of funding sources: None. Introduction The implantable cardioverter-defibrillator (ICD) is an established therapy for the prevention of sudden cardiac death in selected patients. Although current guidelines apply to both women and men, there is a growing awareness that the incidence of cardiac arrhythmias and device interventions is influenced by sex. Purpose To investigate sex-specific risk of sustained ventricular arrhythmias (SVAs) and device therapies, using remote monitoring data from ICDs and cardiac resynchronization therapy defibrillators (CRT-Ds). Methods Study endpoints were time to the first appropriate SVA, time to the first appropriate device therapy for SVA, and time to the first ICD shock. Appropriateness of device-detected SVAs was adjudicated by three expert electrophysiologists. Results were compared between women and a 1:1 propensity score (PS)-matched subgroup of men. Results In a cohort of 2,532 patients with an ICD or CRT-D (median age, 70 years), 488 patients (19.3%) were women. As compared to men, women more frequently had a CRT-D (51% vs. 40%, p Conclusion In our analysis of remote monitoring data, women exhibited a lower SVA risk profile than PS-matched men in the subgroup of patients with an ICD or/and ejection fraction ≥30%.
- Subjects :
- Physiology (medical)
Cardiology and Cardiovascular Medicine
Subjects
Details
- ISSN :
- 15322092 and 10995129
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- EP Europace
- Accession number :
- edsair.doi...........744fbf8cf11d9dafebaf413e1e23760c