Cu(OTf)2-Catalyzed Dehydrogenative C-H Activation under Atmospheric Oxygen: An Expedient Approach to Pyrrolo[3,2-d]pyrimidine Derivatives

A new dehydrogenative C–H activation of uracil in an open atmosphere was developed to synthesize pyrrolo-pyrimidines, which are potentially bioactive molecules. This new approach establishes the selective catalytic activity of Cu(OTf)2 to accomplish the uracil C-6–H activation.