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Roadmap for Achieving Universal Antiretroviral Treatment

Authors :
Simiso Sokhela
Samanta Lalla-Edward
Mark J. Siedner
Mohammed Majam
Willem Daniel Francois Venter
Source :
Annual Review of Pharmacology and Toxicology. 63:99-117
Publication Year :
2023
Publisher :
Annual Reviews, 2023.

Abstract

Modern antiretroviral therapy safely, potently, and durably suppresses human immunodeficiency virus (HIV) that, if left untreated, predictably causes acquired immunodeficiency syndrome (AIDS), which has been responsible for tens of millions of deaths globally since it was described in 1981. In one of the most extraordinary medical success stories in modern times, a combination of pioneering basic science, innovative drug development, and ambitious public health programming resulted in access to lifesaving, safe drugs, taken as an oral tablet daily, for most of the world. However, substantial challenges remain in the fields of prevention, timely access to diagnosis, and treatment, especially in pediatric and adolescent patients. As HIV-positive adults age, treating their comorbidities will require understanding the course of different chronic diseases complicated by HIV-related and antiretroviral toxicities and finding potential treatments. Finally, new long-acting antiretrovirals on the horizon promise exciting new options in both the prevention and treatment fields.

Subjects

Subjects :
Pharmacology
Toxicology

Details

ISSN :
15454304 and 03621642
Volume :
63
Database :
OpenAIRE
Journal :
Annual Review of Pharmacology and Toxicology
Accession number :
edsair.doi...........75522c031f17a85680c54fba85bbef5e
Full Text :
https://doi.org/10.1146/annurev-pharmtox-052020-094321